TABLE III.
Differentially-Expressed Genes that Participate in Identified KEGG Pathways
| Gene ID | Gene Product | Additional KEGG Pathways |
|---|---|---|
| Phosphatidylinositol Signaling System (PSS) | ||
| Calm2 | Calmodulin 2 | LTP. ISP. AD |
| Calm3 | Calmodulin 3 | LTP |
| Dgkg | Diacylglycerol kinase γ | |
| Cardiac Muscle Contraction (CMC) | ||
| 1110020P15 Rik | RIKEN cDNA | PD, AD, HD |
| Atp1b1 | ATPase, Na+/K+, β1 subunit | |
| Atp1b2 | ATPase, Na+/K+, β2 subunit | |
| Cox5b | Cytochrome c oxidase, subunit Vb | PD, AD, HD |
| Cox6a1 | Cytochrome c oxidase, subunit VIa, polypeptide1 | PD, AD, HD |
| Cox 6b1 | Cytochrome c oxidase, subunit VIb, polypeptide 1 | PD, AD, HD |
| Cox7a2l | Cytochrome c oxidase, subunit VIIa, polypeptide 2-like | PD, AD, HD |
| Uqcr | Ubiquinol-cytochrome c reductase subunit | PD, AD, HD |
| Uqcrc2 | Ubiquinol-cytochrome c reductase core protein 2 | PD, AD, HD |
| Uqcrh | Ubiquinol-cytochrome c reductase hinge protein | PD, AD, HD |
| Gap Junction (GJ) | ||
| Gja1 | Gap junction protein, α1 | |
| Tuba1a | Tubulin, α 1A | |
| Tuba1b | Tubulin, α 1B | |
| Tubb4 | Tubulin, β 4 | |
| Tubb5 | Tubulin, β 5 | |
| Long-Term Potentiation (LTP) | ||
| Calm2 | Calmodulin 2 | PSS |
| Calm3 | Calmodulin 3 | PSS, ISP, AD |
| Ppp1ca | Protein phosphatase 1, catalytic subunit, α isoform | ISP |
| Insulin Signaling Pathway (ISP) | ||
| Calm2 | Calmodulin 2 | PSS, LTP, AD |
| Calm3 | Calmodulin 3 | PSS, LTP, AD |
| Ppp1ca | Protein phosphatase 1, catalytic subunit, α isoform | LTP |
| Prkar1a | Protein kinase, cAMP dependent, type I, α | |
| Rps6 | Ribosomal protein S6 | R |
| Parkinson’s Disease (PD) | ||
| 1110020P15 Rik | RIKEN cDNA | CMC, AD, HD |
| Atp5b | ATP synthase, H+ transporting, MT F1 complex, β subunit | AD |
| Atp5g3 | ATP synthase, H+ transporting, MT F0 complex, subunit c, iso 3 | AD, HD |
| Cox7a2l | Cytochrome c oxidase, subunit VIIa, polypeptide 2-like | CMC, AD, HD |
| Ndufa10 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 10 | AD, HD |
| Ndufa2 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 2 | AD, HD |
| Ndufa3 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 3 | AD, HD |
| Ndufa7 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 7 | AD, HD |
| Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 | AD, HD |
| Snca | Synuclein, α | AD |
| Ubb | Ubiquitin B | |
| Uchl1 | Ubiquitin carboxyterminal hydrolase L1 | |
| Uqcr | Ubiquinol-cytochrome c reductase subunit | CMC, AD, HD |
| Uqcrc2 | Ubiquinol-cytochrome c reductase core protein 2 | CMC, AD, HD |
| Uqcrh | Ubiquinol-cytochrome c reductase hinge protein | CMC, AD, HD |
| Ribosomes (R) | ||
| Rpl10 | Ribosomal protein 10 | |
| Rpl10a | Ribosomal protein L10a | |
| Rpl24 | Ribosomal protein 24 | |
| Rpl27 | Ribosomal protein 27 | |
| Rpl41 | Ribosomal protein L41 | |
| Rpl9 | Ribosomal protein L9 | |
| Rplp1 | Ribosomal protein, large, P1 | |
| Rps12 | Ribosomal protein S12 | |
| Rps14 | Ribosomal protein S14 | |
| Rps16 | Ribosomal protein S16 | |
| Rps2 | Ribosomal protein S2 | |
| Rps6 | Ribosomal protein S6 | ISP |
| Rps21 | Ribosomal protein S21 | |
| Rps29 | Ribosomal protein S29 | |
| Rps4x | Ribosomal protein S4, X-linked | |
| Rps7 | Ribosomal protein S7 | |
| Rps9 | Ribosomal protein S9 | |
| Alzheimer’s Disease (AD) | ||
| Apbb1 | Amyloid β precursor protein-binding, family B, 1 | |
| Atp5b | ATP synthase, H+ transporting, MT F1 complex, β subunit | PD |
| Atp5g3 | ATP synthase, H+ transporting, MT F0 complex, subunit c, isoform 3 | PD, HD |
| Calm2 | Calmodulin 2 | PSS, LTP, ISP |
| Calm3 | Calmodulin 3 | PSS, LTP, ISP |
| Cox5b | Cytochrome c oxidase, subunit Vb | CMC, PD, HD |
| Cox6a1 | Cytochrome c oxidase, subunit VIa, polypeptide1 | CMC, PD, HD |
| Cox 6b1 | Cytochrome c oxidase, subunit VIb, polypeptide 1 | CMC, PD, HD |
| Cox7a2l | Cytochrome c oxidase, subunit VIIa, polypeptide 2-like | CMC, PD, HD |
| Ndufa10 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 10 | PD, HD |
| Ndufa2 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 2 | PD, HD |
| Ndufa3 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 3 | PD, HD |
| Ndufa7 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 7 | PD, HD |
| Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 | PD, HD |
| Snca | Synuclein, α | PD |
| Uqcr | Ubiquinol-cytochrome c reductase subunit | CMC, PD, HD |
| Uqcrc2 | Ubiquinol-cytochrome c reductase core protein 2 | CMC, PD, HD |
| Uqcrh | Ubiquinol-cytochrome c reductase hinge protein | CMC, PD, HD |
| Huntington’s Disease (HD) | ||
| 1110020P15Rik | RIKEN cDNA | CMC, PD, AD |
| Atp5g3 | ATP synthase, H+ transporting, MT F0 complex, subunit c, iso 3 | PD, AD |
| Cox5b | Cytochrome c oxidase, subunit Vb | CMC, PD, AD |
| Cox6a1 | Cytochrome c oxidase, subunit VIa, polypeptide1 | CMC, PD, AD |
| Cox 6b1 | Cytochrome c oxidase, subunit VIb, polypeptide 1 | CMC, PD, AD |
| Cox7a2l | Cytochrome c oxidase, subunit VIIa, polypeptide 2-like | CMC, PD, AD |
| Gpx1 | Glutathioneperoxidase 1 | |
| Ndufa10 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 10 | PD, AD |
| Ndufa2 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 2 | PD, AD |
| Ndufa3 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 3 | PD, AD |
| Ndufa7 | NADH dehydrogenase (ubiquinone), 1α, subcomplex 7 | PD, AD |
| Ndufv1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 | PD, AD |
| Uqcr | Ubiquinol-cytochrome c reductase subunit | CMC, PD, AD |
| Uqcrc2 | Ubiquinol-cytochrome c reductase core protein 2 | CMC, PD, AD |
| Uqcrh | Ubiquinol-cytochrome c reductase hinge protein | CMC, PD, AD |
Pathways are presented in decreasing order of impact factors, as in Table II. Phosphatidylinositol signaling system, PSS; Cardiac muscle contraction, CMC; Gap junction, GJ; Long-term potentiation, LTP; Insulin signaling pathway, ISP; Parkinson’s disease, PD; Alzheimer’s disease, AD; Huntington’s disease, HD.