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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Ann Surg. 2015 Feb;261(2):368–377. doi: 10.1097/SLA.0000000000000635

Figure 3. Comparative effects of ADH-1 treatment on signaling pathways in the A375 and DM443.

Figure 3

RPPA analysis was performed on xenografts of the A375 (Black bars) and the DM443 (Gray bars) harvested one hour after treatment with saline or ADH-1 as outlined in Figure 1. The effects of ADH-1 treatment were determined by subtracting the exponential value of the relative expression for each of the indicated proteins following saline treatment from the observed expression following ADH-1 treatment. Proteins with a relative change of >0 were increased with ADH-1 treatment; <0 indicates inhibition with ADH-1 treatment. (a.), expression of total- and phospho-proteins in the PI3K-AKT pathway. (b.) expression of total and phospho-proteins in other pro-survival kinase signaling pathways.