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. Author manuscript; available in PMC: 2015 May 14.
Published in final edited form as: Cell Rep. 2015 Apr 30;11(6):967–976. doi: 10.1016/j.celrep.2015.04.011

Figure 6. LRP1 and LRP1-AS dysregulation in Alzheimer disease.

Figure 6

Quantitative RT-PCR analysis of LRP1 (A) and LRP1-AS (B) expression in superior frontal gyrus of 15 patients with Alzheimer’s disease (AD) and 8 control subjects (Ctrl). The housekeeping gene β-ACTIN was used as endogenous control; LRP1 and LRP1-AS expression was normalized to Ctrl. ***P<0.001 determined by ANOVA.

(C) A Model Proposing Functional and Physical Interactions Between Lrp1-AS, Srebp1a and Hmgb2 on the Lrp1 Promoter. Hmgb2 can bind with Srebp1a, and induces Lrp1 promoter activity containing SRE-like motifs (depicted in gray boxes). When Lrp1-AS is depleted or treated with antagoNATs, cooperative activation of Lrp1 expression by Hmgb2 and Srebp1a is enhanced.