Figure 5.

Platelet TLR4 contributes to cellular Fn-EDA+-mediated accelerated thrombosis in injured arteries. (A) Schematic depicting the technique for generating chimeric mice with platelet-specific TLR4 deficiency. (B-D) Graphs representing mean time to first thrombus formation (B), thrombus growth (C), and mean time to occlusion (D) in FeCl₃-injured carotid arteries. *P < .05 compared with mice infused with Fn-EDA^+/+/TLR4^−/− platelets. Data are presented as mean ± SEM. N = 9 to 10 mice per group.