Table 1.
Demographics and other baseline characteristics
| Placebo (n = 161) | Vortioxetine 15 mg (n = 147) | Vortioxetine 20 mg (n = 154) | Duloxetine 60 mg (n = 152) | |
|---|---|---|---|---|
| Age, mean (±SD) (years) | 42.4 (±12.55) | 43.1 (±12.28) | 42.8 (±12.40) | 43.4 (±12.24) |
| Range | 20–73 | 21–75 | 19–72 | 19–72 |
| Female, n (%) | 116 (72.0) | 104 (70.7) | 114 (74.0) | 119 (78.3) |
| Race, n (%) | ||||
| White | 122 (75.8) | 114 (77.6) | 115 (74.7) | 119 (78.3) |
| Black | 37 (23.0) | 31 (21.1) | 36 (23.4) | 32 (21.1) |
| Asian | 1 (0.6) | 2 (1.4) | 3 (1.9) | 1(0.7) |
| Native American/Alaskan native | 1 (0.6) | 0 | 0 | 0 |
| BMI, mean (±SD) (kg/m2) | 31.1 (±7.88) | 31.3 (±7.48) | 30.9 (±7.63) | 31.5 (±8.45) |
| MADRS total score, mean (±SD) | 31.6 (±4.18) | 31.9 (±4.08) | 32.0 (±4.36) | 32.9 (±4.39) |
| HAM-A total score, mean (±SD) | 17.0 (±5.12) | 17.5 (±5.28) | 17.8 (±5.42) | 18.4 (±5.81) |
| CGI-S total score, mean (±SD) | 4.6 (±0.58) | 4.5 (±0.55) | 4.5 (±0.60) | 4.5 (±0.60) |
BMI body mass index, CGI-S Clinical Global Impression–Severity, HAM-A Hamilton Anxiety Rating Scale, MADRS Montgomery–Åsberg Depression Rating Scale, SD standard deviation