TABLE 3.
Logistic regression analysis of predictors associated with vancomycin treatment failurea
| Factor | Odds ratio (95% CI) |
P | |
|---|---|---|---|
| Unadjusted | Adjusted | ||
| VAN AUC0–24/MICBMD ratio of ≤600 | 1.910 (0.939-3.885) | 2.331 (1.012–5.371) | 0.047 |
| Admission to ICU | 2.878 (1.367–6.058) | 3.572 (1.535–8.313) | 0.003 |
| hVISA | 3.699 (1.027–13.321) | 4.588 (1.154–18.242) | 0.031 |
| Previous hospitalization | 0.480 (0.236–0.979) | 0.370 (0.160–0.858) | 0.021 |
| IDU | 0.596 (0.278–1.281) | 0.422 (0.170–1.050) | 0.064 |
| Age | 1.032 (0.997–1.069) | 1.033 (0.999–1.069) | 0.057 |
a
VAN, vancomycin; AUC0–24, area under the concentration 24-h time curve; BMD, broth microdilution; ICU, intensive care unit; hVISA, heterogeneous vancomycin-intermediate S. aureus; IDU, intravenous drug user.