TABLE 3.

Statistical comparisons between the conidial (standard) and fragmented-mycelium inoculum using CLSI and EUCAST guidelines^a

Guideline	AFAb	nc	Concn range (mg/liter) for method:				P value
			Conidium		Fragmented mycelium
			MIC	MEC	MIC	MEC
CLSId	AMP	18	0.06–1.0		0.25–1.0		0.011
	TER	18	0.03–0.06		0.03–0.06		1.000
	FLC	18	0.125–32.0		0.25–32.0		1.000
	POS	18	0.06–1.0		0.06–2.0		0.929
	VRC	18	0.03–2.0		0.03–0.5		0.404
	ITR	18	0.06–2.0		0.06–2.0		0.674
	MCA	18		0.016–0.125		0.016–16.0	0.472
	ANI	18		0.016–0.03		0.016–16.0	0.461
	CAS	18		0.125–2.0		0.06–1.0	0.660
EUCASTe	AMP	18	0.25–2.0		0.125–2.0		0.149
	TER	18	0.03–0.125		0.03–0.125		0.180
	FLC	18	1.0–64.0		0.06–64.0		0.674
	POS	18	0.25–2.0		0.03–1.0		0.440
	VRC	18	0.03–2.0		0.03–0.5		0.141
	ITR	18	0.25–8.0		0.03–1.0		0.306
	MCA	18		0.03–1.0		0.03–0.125	1.000
	ANI	18		0.016–1.0		0.016–0.25	0.483
	CAS	18		0.06–0.5		0.03–0.5	0.905

^aTested clinical strains included Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans, and Microsporum canis.

^bTested antifungal agents (AFAs): amphotericin B (AMP), terbinafine (TER), fluconazole (FLC), posaconazole (POS), voriconazole (VRC), itraconazole (ITR), micafungin (MCA), anidulafungin (ANI), and caspofungin (CAS).

^cNumber of isolates; each isolate was tested once.

^dMicrodilution testing according to Clinical and Laboratory Standards Institute (CLSI) guidelines (6).

^eMicrodilution testing according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines (7).