TABLE 6.
Antifungal activities of antifungal agents against clinical isolates of Microsporum canis, T. mentagrophytes, T. rubrum, and Trichophyton tonsuransc
| Organism (n = 20b) | AFAa | Concn range (mg/liter) |
Characteristic MIC or MEC value (mg/liter) |
||||
|---|---|---|---|---|---|---|---|
| MIC | MEC | MIC50 | MEC50 | MIC90 | MEC90 | ||
| Microsporum canis | VRC | 0.06–32.00 | 0.25 | 32.00 | |||
| PSC | 0.13–3.00 | 1.00 | 2.00 | ||||
| FLC | 2.00–256.00 | 32.00 | 256.00 | ||||
| AMB | 0.06–0.50 | 0.25 | 0.40 | ||||
| ANI | 0.00–0.03 | 0.01 | 0.03 | ||||
| CAS | 0.00–0.02 | 0.02 | 0.02 | ||||
| MCA | 0.00–0.03 | 0.01 | 0.03 | ||||
| Trichophyton mentagrophytes | VRC | 0.01–1.00 | 0.06 | 0.25 | |||
| PSC | 0.02–1.00 | 0.06 | 0.25 | ||||
| FLC | 2.00–128.00 | 16.00 | 64.00 | ||||
| AMB | 0.13–1.00 | 0.25 | 0.50 | ||||
| ANI | 0.00–0.06 | 0.01 | 0.02 | ||||
| CAS | 0.00–0.25 | 0.03 | 0.06 | ||||
| MCA | 0.00–1.00 | 0.13 | 0.50 | ||||
| Trichophyton rubrum | VRC | 0.01–32.00 | 0.06 | 0.13 | |||
| PSC | 0.02–0.50 | 0.05 | 0.38 | ||||
| FLC | 1.00–256.00 | 16.00 | 32.00 | ||||
| AMB | 0.13–0.25 | 0.13 | 0.25 | ||||
| ANI | 0.00–0.06 | 0.01 | 0.06 | ||||
| CAS | 0.03–0.13 | 0.06 | 0.13 | ||||
| MCA | 0.00–0.06 | 0.01 | 0.50 | ||||
| Trichophyton tonsurans | VRC | 0.02–1.00 | 0.25 | 0.55 | |||
| PSC | 0.03–0.25 | 0.06 | 0.25 | ||||
| FLC | 2.00–64.00 | 24.00 | 64.00 | ||||
| AMB | 0.13–0.25 | 0.13 | 0.25 | ||||
| ANI | 0.00–0.03 | 0.02 | 0.06 | ||||
| CAS | 0.01–0.02 | 0.02 | 0.06 | ||||
| MCA | 0.00–0.03 | 0.00 | 0.06 | ||||
a
Tested antifungal agents (AFAs): voriconazole (VRC), posaconazole (PSC), fluconazole (FLC), amphotericin B (AMB), anidulafungin (ANI), caspofungin (CAS), and micafungin (MCA).
b
Number of replicates tested with the same quality control strain.
c
Activity was evaluated using the fragmented-mycelium inoculum preparation (modified EUCAST) method.