TABLE 1.
In vitro MICsa of kibdelomycin and the quinolone levofloxacin
| Organism | Phenotype | MIC (μg/ml) |
|
|---|---|---|---|
| Kibdelomycin | Levofloxacin | ||
| Gram-positive bacteria | |||
| S. aureus Smith | Wild type | 0.25 | 0.125 |
| S. aureus OITI 1-971 | MRSA clinical isolate | 0.25 | 32 |
| S. pneumoniae IID553 | Wild type | 0.25 | 1 |
| E. faecium A2373 | Vancomycin resistant | 1 | 4 |
| Gram-negative bacteria | |||
| E. coli ATCC 25922 | Wild type | >16 | 0.031 |
| E. coli TG1 | Wild type | >16 | 0.031 |
| P. aeruginosa PAO1 | Wild type | >16 | 0.5 |
| P. aeruginosa PAO4009 | Wild type | >16 | 0.5 |
| P. aeruginosa KH4013E (nfxB) | MexCD-OprJ overexpressed | >16 | 2 |
| P. aeruginosa KH4014a (nfxC) | MexEF-OprN overexpressed | >16 | 8 |
| P. aeruginosa PAO969 | Wild type | >16 | 0.5 |
| P. aeruginosa PAO6006 (nalB) | MexAB-OprM overexpressed | 16 | 4 |
| P. aeruginosa TOHOKU1 | Multidrug resistant | 16 | 64 |
| A. baumannii IID876 | Wild type | 2 | 0.125 |
a
MICs were determined by the CLSI agar diffusion method. All strains were obtained from the ATCC or the Japanese Society of Bacteriology. P. aeruginosa strains KH4013E (nfxB) and KH4014a (nfxC) were prepared from PAO4009, and PAO6006 (nalB) was prepared from PAO6006 (16).