TABLE 3.

Comparative in vitro MICs^a of kibdelomycin, linezolid, vancomycin, and levofloxacin for 196 clinical bacterial strains

Organism (no. of isolates) and antimicrobial agent	MIC (μg/ml)
	50% of strains	90% of strains	Range
S. aureus (57)
Kibdelomycin	1.00	2.00	0.25–4.00
Linezolid	2.00	16	1.00 to >16
Vancomycin	1.00	4.00	0.50 to >32
Levofloxacin	8	>16	0.25 to >16
S. epidermidis (7)
Kibdelomycin	ND	ND	2.00–8.00
Linezolid	ND	ND	1.00–2.00
Vancomycin	ND	ND	1.00–2.00
Levofloxacin	ND	ND	0.50–8.00
Coagulase-negative Staphylococcus (8)
Kibdelomycin	ND	ND	0.50–8.00
Linezolid	ND	ND	1.00–2.00
Vancomycin	ND	ND	0.50–2.00
Levofloxacin	ND	ND	0.125–16
S. pneumoniae (22)
Kibdelomycin	2.00	2.00	0.25–4.00
Linezolid	1.00	1.00	≤0.25–1.00
Vancomycin	0.25	0.25	0.25–0.50
Levofloxacin	0.50	16	0.50–16
S. pyogenes (15)
Kibdelomycin	4.00	4.00	2.00–8.00
Linezolid	1.00	1.00	0.50–1.00
Vancomycin	0.25	0.25	0.25–0.50
Levofloxacin	0.50	0.50	0.25–2.00
E. faecalis (21)
Kibdelomycin	0.50	2.00	0.25–2.00
Linezolid	1.00	1.00	0.50–1.00
Vancomycin	2.00	>32	1.00 to >32
Levofloxacin	>16	>16	1.00 to >16
E. faecium (18)
Kibdelomycin	4.00	4.00	2.00–4.00
Linezolid	2.00	2.00	1.00–2.00
Vancomycin	>32	>32	0.50 to >32
Levofloxacin	>16	>16	1.00 to >16
M. catarrhalis (12)
Kibdelomycin	0.25	0.50	≤0.015–1.00
Linezolid	4.00	4.00	2.00–4.00
Vancomycin	>32	>32	32 to >32
Levofloxacin	1	2	0.5–4
H. influenzae (17)
Kibdelomycin	2.00	4.00	0.50–8.00
Linezolid	>16	>16	8.00 to >16
Vancomycin	>32	>32	32 to >32
Levofloxacin	0.015	0.03	0.015–0.03
A. baumannii (19)
Kibdelomycin	≤0.015	0.125	≤0.015 to >32
Linezolid	>16	>16	>16
Vancomycin	>32	>32	>32
Levofloxacin	8	>16	0.03 to >16

^aMICs were determined by the CLSI broth microdilution method.