TABLE 1.
Treatment (no. of rabbits) | Median organism titer, log10 CFU/g (IQD)a |
P value vs: |
|||||||
---|---|---|---|---|---|---|---|---|---|
Vegetation | Spleen | Kidney | Control |
Tedizolid phosphate |
|||||
Vegetation | Spleen | Kidney | Vegetation | Spleen | Kidney | ||||
Control (8) | 7.9 (2.2) | 4.7 (1.3) | 3.4 (2.8) | Refb | Ref | Ref | 0.026 | 0.006 | 0.057 |
Tedizolid phosphate, 15 mg/kg i.v. b.i.d. (15) | 6.4 (3.4) | 3.0 (2.5) | 2.3 (1.3) | 0.026 | 0.006 | 0.057 | Ref | Ref | Ref |
Daptomycin, 18 mg/kg i.v. q.d. (14) | 2.7 (1.4) | 1.8 (0.2) | 1.7 (0.2) | 0.002 | <0.001 | 0.002 | 0.016 | 0.430 | 0.112 |
Vancomycin, 30 mg/kg i.v. b.i.d. (14) | 5.5 (3.9) | 2.7 (3.8) | 2.0 (1.6) | 0.051 | 0.022 | 0.044 | 0.984 | 0.646 | 0.928 |
IQD, interquartile difference.
Ref, reference.