TABLE 1.

Comparative study of tedizolid phosphate, daptomycin, and vancomycin

Treatment (no. of rabbits)	Median organism titer, log10 CFU/g (IQD)a			P value vs:
	Vegetation	Spleen	Kidney	Control			Tedizolid phosphate
				Vegetation	Spleen	Kidney	Vegetation	Spleen	Kidney
Control (8)	7.9 (2.2)	4.7 (1.3)	3.4 (2.8)	Refb	Ref	Ref	0.026	0.006	0.057
Tedizolid phosphate, 15 mg/kg i.v. b.i.d. (15)	6.4 (3.4)	3.0 (2.5)	2.3 (1.3)	0.026	0.006	0.057	Ref	Ref	Ref
Daptomycin, 18 mg/kg i.v. q.d. (14)	2.7 (1.4)	1.8 (0.2)	1.7 (0.2)	0.002	<0.001	0.002	0.016	0.430	0.112
Vancomycin, 30 mg/kg i.v. b.i.d. (14)	5.5 (3.9)	2.7 (3.8)	2.0 (1.6)	0.051	0.022	0.044	0.984	0.646	0.928

^aIQD, interquartile difference.

^bRef, reference.