TABLE 4.
Statistical comparison of tedizolid phosphate at doses of 2, 4, and 8 mg/kg i.v. b.i.d.
| Tedizolid phosphate dose, mg/kg i.v. b.i.d. (no. of rabbits) | Median organism titer, log10 CFU/g (IQD)a |
P value for each treatment vs 2-mg/kg dose |
||||
|---|---|---|---|---|---|---|
| Vegetation | Spleen | Kidney | Vegetation | Spleen | Kidney | |
| 2 (9) | 9.3 (0.5) | 5.9 (0.6) | 4.8 (1.1) | Refb | Ref | Ref |
| 4 (11) | 8.5 (0.6) | 5.4 (1.0) | 4.4 (1.2) | <0.001 | 0.036 | 0.095 |
| 8 (10) | 8.1 (0.8) | 5.0 (1.1) | 3.6 (1.7) | <0.001 | 0.051 | 0.013 |
a
IQD, interquartile difference.
b
Ref, reference.