FIG 2.

Tulathromycin efficiently controls high Plasmodium parasite burden. C57BL/6N mice were infected with Plasmodium yoelii at time zero (n = 37, 7 to 8 mice per group). Groups of mice were treated with azithromycin (Azin; n = 7), tulathromycin (Tuln; n = 8), artemether (Art; n = 7), or tulathromycin plus artemether (Tul+Art; n = 8). All the treatments were started at day 15 postinfection until resolution of the infection. A group of infected mice remained untreated, representing the control group (n = 7). (A) Percent parasitemia on the indicated days. (B) Area under the parasitemia-time curve (AUC) for each group during the period after drug administration until resolution of the infection. Data (mean ± standard error of the mean) are cumulative data from two independent experiments. *, P < 0.05; **, P < 0.01; ****, P < 0.0001; NS, not significant.