TABLE 6.
Population pharmacokinetic parameters of vancomycin estimated in the entire population study (n = 78 patients, 376 vancomycin concentrations)
| Model and type of resultb | CLNR (liters/h) | CLSa | KCP (h−1) | KPC (h−1) | V (liters) |
|---|---|---|---|---|---|
| CG | |||||
| Mean | 0.60 | 0.42 | 0.20 | 0.10 | 44.3 |
| Median (IQR) | 0.37 (0.23–1.08) | 0.39 (0.20–0.61) | 0.086 (0.031–0.21) | 0.074 (0.021–0.15) | 44.3 (33.4–56.4) |
| CV (%) | 89.1 | 67.6 | 141.7 | 104.8 | 48.4 |
| JEL | |||||
| Mean | 0.71 | 0.37 | 0.73 | 0.32 | 35.1 |
| Median (IQR) | 0.34 (0.17–1.15) | 0.32 (0.17–0.51) | 0.27 (0.047–0.90) | 0.13 (0.043–0.19) | 35.0 (14.6–47.9) |
| CV (%) | 103.4 | 69.7 | 205.5 | 314.9 | 64.4 |
| MDRD | |||||
| Mean | 0.67 | 0.27 | 0.28 | 0.14 | 41.1 |
| Median (IQR) | 0.46 (0.27–1.14) | 0.28 (0.085–0.4) | 0.12 (0.036–0.39) | 0.078 (0.012–0.17) | 38.2 (28.0–54.7) |
| CV (%) | 107.2 | 74.9 | 109.0 | 148.7 | 51.7 |
| MDRDm | |||||
| Mean | 0.72 | 0.29 | 0.43 | 0.52 | 40.7 |
| Median (IQR) | 0.42 (0.18–0.95) | 0.30 (0.10–0.41) | 0.14 (0.046–0.26) | 0.094 (0.040–0.23) | 41.2 (36.3–54.9) |
| CV (%) | 124.7 | 70.1 | 175.5 | 274.6 | 43.3 |
| CKD-EPI | |||||
| Mean | 0.55 | 0.34 | 0.17 | 0.11 | 44.6 |
| Median (IQR) | 0.36 (0.23–0.89) | 0.32 (0.19–0.44) | 0.075 (0.030–0.20) | 0.045 (0.017–0.14) | 43.5 (31.2–54.0) |
| CV (%) | 94.2 | 53.1 | 133.3 | 163.1 | 51.7 |
| CKD-EPIm | |||||
| Mean | 0.44 | 0.38 | 0.19 | 0.15 | 44.5 |
| Median (IQR) | 0.33 (0.22–0.60) | 0.35 (0.17–0.55) | 0.092 (0.027–0.24) | 0.055 (0.015–0.19) | 42.9 (29.9–57.8) |
| CV (%) | 116.7 | 68.1 | 136.7 | 163.8 | 49.1 |
a
The unit of CLS is liters per hour per unit of CLCR or GFR (liters/hour or liters/hour per1.73 m2), depending on the renal function estimation equation. For example, with the CG-based model, the mean vancomycin renal clearance for a subject with a creatinine clearance of 6 liters/h (100 ml/min) is: 0.42 × 6 = 2.52 liters/h.
b
IQR, interquartile range; CV, coefficient of variation.