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(Left) Structure of N-PE-PanAm (compound 2), which can be degraded by pantetheinase (Vanin) to form pantothenate (compound 1) and phenethylamine. (Right) Structure of α-Me-N-PE-PanAm (compound 3), which shows limited degradation by pantetheinase. The vulnerable (scissile) amide bond is indicated by the oval on the left, while the shaded oval on the right shows how it is modified by introduction of the methyl group to increase stability.
