TABLE 4.

Pharmacokinetic parameters for RPT and desRPT among ACTG study A5311 participants using NCA^a

Pharmacokinetic parameter	Dosing cohort	No. of participants	RPT		desRPT
			Median	IQR	Median	IQR
AUC0–24ss (μg · h/ml)	20 mg/kg QD	9	580	521–637	467	256–689
	10 mg/kg BID	10	756	681–898	918	666–1,014
	15 mg/kg with an LFB	19	689	611–860	556	487–803
	15 mg/kg with an egg	19	715	577–1,037	687	537–932
Cmin (μg/ml)	20 mg/kg QD	9	13	1–17	10	0.5–23
	10 mg/kg BID	10	22	19–30	27	19–35
	15 mg/kg with an LFB	19	14	12–25	13	11–21
	15 mg/kg with an egg	19	18	13–23	22	15–29
Cmax (μg/ml)	20 mg/kg QD	9	39	32–45	25	14–37
	10 mg/kg BID	10	39	35–44	44	34–48
	15 mg/kg with an LFB	19	42	34–49	30	24–40
	15 mg/kg with an egg	19	44	36–61	38	28–46

^aQD, once daily; BID, twice daily; LFB, low-fat breakfast; C_min, minimum concentration in plasma.