TABLE 1.
Pharmacokinetic parameter estimates of ceftolozane and tazobactam in thigh-infected neutropenic mice
| Drug | No. of curvesa | Pharmacokinetic parametersb |
|||||
|---|---|---|---|---|---|---|---|
| CL (liter/h/kg) |
t1/2 (min) |
V (liter/kg) |
|||||
| Estimate | SD | Estimate | SD | Estimate | SD | ||
| Ceftolozane (overall) | 15 | 1.33 | 0.32 | 17.2 | 1.86 | 0.43 | 0.15 |
| Without tazobactam | 7 | 1.32 | 0.38 | 18.1 | 2.36 | 0.47 | 0.18 |
| With tazobactam | 8 | 1.33 | 0.29 | 16.5 | 0.80 | 0.39 | 0.10 |
| Tazobactam | 10 | 4.64 | 1.46 | 10.6 | 1.57 | 1.14 | 0.56 |
a
Drug doses of 4 to 64 mg/kg.
b
CL, clearance; t1/2, half-life; V, volume of distribution.