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. 2015 May 14;59(6):3373–3376. doi: 10.1128/AAC.04402-14

TABLE 2.

Penetration of ceftolozane and tazobactam in ELF for total drug and protein-unbound drug

Drug Dose, mg/kg Total plasma AUC (mg · h/liter) Total ELF AUC (mg · h/liter) Total ELF/plasma ratio Free ELF/plasma ratioa
Ceftolozane 8 6.86 2.20 0.32 0.34
32 21.64 6.42 0.30 0.31
Tazobactam 8 2.05 0.91 0.45 0.60
32 7.25 4.51 0.62 0.83
a

Free-drug ELF/free-drug plasma.