TABLE 1.

Activity of a set of 20 antimalarial drugs in the P. falciparum FGAA for comparison of high- and low-throughput formats

Drug	% inhibition of female gametocyte activationa
	High-throughput format		Low-throughput formatb
	Mean	SD	Mean	SEM
Amodiaquine	34.6	5.3	27.25	4.5
Artemether	28.2	8.7	9.97	11.48
Artemisinin	27.9	13.7	11.44	8.23
Artesunate	38.9	14.7	10.3	2.3
Azithromycin	19.4	5.2	12.95	6.92
Chloroquine	13.7	10.3	NDc	ND
Cycloguanil	11.9	9.1	17.63	5.27
Cycloheximide	86.9	11.5	ND	ND
Dihydroartemisinin	43.3	15.1	9.36	4.26
Doxycycline	9.0	10.4	45.41	3.18
Halofantrine	15.6	10.9	−0.89	9.63
Lumefantrine	14.1	11.2	ND	ND
Mefloquine	64.3	12.0	34.2	9.21
Methylene blue	42.0	17.6	95.82	1.99
Primaquine	21.7	13.2	17.77	11.22
Pyrimethamine	16.9	12.2	7.43	6.52
Pyronaridine	100.0	2.7	95.56	1.17
Quinine	11.2	8.8	ND	ND
Sulfadoxine	10.4	11.7	ND	ND
Thiostrepton	97.4	1.2	97.85	0.46

^aData are mean percent inhibition values with respect to the level of inhibition for the DMSO carrier controls (n = 6) ± SD when each of the drugs was used at a concentration of 10 μM.

^bData are from Delves et al. (21).

^cND, not determined.