TABLE 1.
Susceptibility of P. aeruginosa to T9W and comparable antimicrobial agents and their cytotoxicities
| Parameter | T9W | Polymyxin B | Amikacin | Ciprofloxacin | Gentamicin | Ceftazidime |
|---|---|---|---|---|---|---|
| MIC (μg/ml)a | 2–4 | 0.5–1 | 0.4–0.8 | 0.8–1.6 | 0.3–0.6 | 0.3–0.6 |
| MHC (μg/ml)b | >290 | >176 | >100 | >50 | >74 | >70 |
| Cytotoxicity (μg/ml)c | >290 | >176 | >100 | >50 | >74 | >70 |
a
The MIC was determined as the lowest concentration of the peptide that inhibited bacterial growth of the reference strain P. aeruginosa ATCC 27853.
b
Minimal hemolytic concentration (MHC) was determined as the lowest concentration of the peptide that caused 10% hemolysis of human red blood cells.
c
Cytotoxicity was determined as the lowest concentration of the peptide that reduced cell viability of RAW264.7 macrophage cells by 10%.