TABLE 1.
Parameter | T9W | Polymyxin B | Amikacin | Ciprofloxacin | Gentamicin | Ceftazidime |
---|---|---|---|---|---|---|
MIC (μg/ml)a | 2–4 | 0.5–1 | 0.4–0.8 | 0.8–1.6 | 0.3–0.6 | 0.3–0.6 |
MHC (μg/ml)b | >290 | >176 | >100 | >50 | >74 | >70 |
Cytotoxicity (μg/ml)c | >290 | >176 | >100 | >50 | >74 | >70 |
The MIC was determined as the lowest concentration of the peptide that inhibited bacterial growth of the reference strain P. aeruginosa ATCC 27853.
Minimal hemolytic concentration (MHC) was determined as the lowest concentration of the peptide that caused 10% hemolysis of human red blood cells.
Cytotoxicity was determined as the lowest concentration of the peptide that reduced cell viability of RAW264.7 macrophage cells by 10%.