TABLE 2.
Lethal concentration values of T9W and comparable antimicrobial agents against P. aeruginosa
| Strain | LC (μg/ml)a |
|||||
|---|---|---|---|---|---|---|
| T9W | Polymyxin B | Amikacin | Ciprofloxacin | Gentamicin | Ceftazidime | |
| 27853 | 4 ± 0.9 | 1 ± 0.3 | 1 ± 0.2 | 25 ± 2.6 | 1 ± 0.2 | 1 ± 0.2 |
| 10419 | 9 ± 0.8 | 11 ± 0.7 | 6 ± 0.3 | 25 ± 3.1 | 5 ± 1.0 | 2 ± 1.0 |
| 21625 | 9 ± 1.8 | 6 ± 0.7 | 13 ± 1.8 | 25 ± 2.1 | 19 ± 2.0 | 4 ± 0.4 |
| 21630 | 9 ± 0.8 | 6 ± 0.7 | 1 ± 0.4 | 25 ± 3.4 | 1 ± 0.6 | 1 ± 0.5 |
| LC | 2 ± 0.5 | 6 ± 1.3 | 0.2 ± 0.2 | 3 ± 0.5 | 0.3 ± 0.1 | 2 ± 0.5 |
| LCCI | 4 ± 0.5 | 6 ± 0.5 | 6 ± 2.9 | >100 | 9 ± 1.9 | 9 ± 1.6 |
| LCGE | 9 ± 1.8 | 2 ± 0.5 | >100 | 50 ± 0 | >148 | 9 ± 1.4 |
| LCCE | 9 ± 1.7 | 6 ± 0.5 | 6 ± 0.6 | 25 ± 2.6 | 5 ± 1.0 | >140 |
| 11441 | 2 ± 0.5 | 11 ± 0.5 | 13 ± 2.5 | 50 ± 0 | 37 ± 3.1 | 70 ± 0 |
| 11451 | 4 ± 0.9 | 6 ± 0.9 | 13 ± 2.5 | 25 ± 0.3 | 37 ± 4.1 | 35 ± 4.3 |
| 21328 | 9 ± 1.8 | 11 ± 0.5 | 100 ± 0 | >50 | >74 | >70 |
| 25349 | 4 ± 0.9 | 2 ± 0.5 | 6 ± 0.6 | 25 ± 2.1 | 5 ± 1.6 | 35 ± 2.7 |
| 26305 | 4 ± 0.8 | 2 ± 0.3 | 3 ± 0.6 | 25 ± 2.4 | 2 ± 0.8 | >70 |
a
Lethal concentration (LC) was defined as the lowest concentration of antimicrobial agent at which there was complete killing. The LCs were derived from representative values (means ± standard errors) of three independent experimental trials.