FIG 1.

Growth competitions of the HIV-1 wild type (WT; open circles) versus the RT-M184V (A), IN-E92Q (B), RT-M184V + IN-E92Q (C), RT-K65R (D), RT-K65R/M184V (E), and RT-K65R/M184V + IN-E92Q (F) mutants (closed circles). MT-2 cells were coinfected with viral stocks mixed at a 50:50 ratio. The proportion of virus at each time point was determined by quantifying viral RNA by real-time allele-specific RT-PCR. Data shown are averages from 3 independent competition experiments with standard deviations. The mean relative fitness (RF; 1 + s) values for the mutant viruses compared to WT are shown in Table 2.