Trends in the prevalence of multidrug-resistant isolates of E. coli from IAIs in the United States in 2009 to 2013. No statistically significant trends were noted in main (all 29 sites) or sensitivity (12 continuously participating sites) analyses (all P > 0.05). MDR, multidrug-resistant; HA, hospital-associated; CA, community-associated. E. coli sample sizes (denominators) were as follows: all (including isolates from HA and CA IAIs, as well as isolates for which the time of collection postadmission was not reported), 2009, 551 isolates; 2010, 613 isolates; 2011, 554 isolates; 2012, 603 isolates; 2013, 576 isolates; HA, 2009, 291 isolates; 2010, 249 isolates; 2011, 213 isolates; 2012, 277 isolates; 2013, 258 isolates; CA, 2009, 184 isolates; 2010, 334 isolates; 2011, 311 isolates; 2012, 326 isolates; 2013, 318 isolates.