TABLE 3.
PK parameters of clofazimine in uninfected mice after daily administration for up to 20 weeks
| Sample | No. of wk of CFZ administration | t½ (wk) | C (μg/unit)a,b | AUC0–∞ (μg · wk/unit)b |
|---|---|---|---|---|
| Serum | 4 | 1.45 | 1.33 | 7.15 |
| 8 | 1.91 | 2.25 | 14.97 | |
| 12 | 6.49 | 2.25 | 25.72 | |
| 16 | 6.29 | 2.25 | 30.18 | |
| 20 | 8.19 | 2.25 | 35.18 | |
| Liver | 4 | 3.09 | 33.26 | 107.96 |
| 8 | 5.57 | 59.97 | 312.19 | |
| 12 | 4.10 | 82.37 | 714.66 | |
| 16 | 3.32 | 111.29 | 1,302.99 | |
| 20 | 2.82 | 156.91 | 2,514.44 | |
| Lung | 4 | 4.33 | 29.98 | 105.27 |
| 8 | 4.27 | 52.59 | 387.34 | |
| 12 | 3.55 | 52.59 | 557.31 | |
| 16 | 4.17 | 52.59 | 739.39 | |
| 20 | 3.36 | 106.11 | 1,188.01 | |
| Spleen | 4 | 4.96 | 50.43 | 180.95 |
| 8 | 1.65 | 1,936.85 | 9,376.44 | |
| 12 | 5.38 | 4,684.68 | 54,082.57 | |
| 16 | 7.18 | 7,297.53 | 113,878.1 | |
| 20 | 13.46 | 9,020.41 | 192,658.5 |
a
C, highest mean concentration observed.
b
Unit, milliliters for serum and grams for liver, lung, and spleen tissue.