TABLE 2.
Benznidazole popPK parameter estimates for the base and final models and bootstrap results for the final model
| Parameter | Base/final popPK model estimate | Mean (95% CI) bootstrap resulta |
|---|---|---|
| Pharmacokinetic parameters | ||
| CL/F (liters/h) | 1.73 | 1.73 (1.54–1.92) |
| V/F (liters) | 89.6 | 92.54 (45.56–133.64) |
| Ka (h−1) | 1.15 (fixed) | |
| IIVb in: | ||
| CL/F | 33.4 | 33.1 (17.3–44.0) |
| V/F | 68.8 | 72.3 (25–94.2) |
| IOVb in: | ||
| CL/F | 29.5 | 29.9 (20.4–36.4) |
| RVc | ||
| σ21 (mg/liter) | 0.57 ± 0.19 | 0.56 (0.12–1.27) |
| σ22 (CV%) | 19.53 | 17.1 (24.1–57.1) |
a
Derived from 200 successful bootstrap sample runs.
b
Estimates of interindividual/interoccasion variability are expressed as coefficients of variation of variance (CVω2).
c
σ21, standard deviation of the additive component of residual variability; σ22, variance of the proportional component of residual variability.