FIG 2.

Placebo-adjusted change from the baseline QTcF (ms) versus time (electrocardiographic [PD] population). A mixed-effect general linear model (placebo adjusted and baseline corrected) was fitted for QTcF (ms) and included terms for treatment, gender, time, baseline value, time-by-treatment interaction, gender-by-baseline interaction of QTcF (ms), and time-by-treatment-by-gender interaction. Gender was a significant effect. Lower and upper bounds = lower and upper 2-sided 90% (1-sided 95%) model-based confidence limits. P values for gender effect were gender main effect = 0.6949, treatment-by-gender interaction = 0.2919, gender-by-baseline interaction = 0.5339, and treatment-by-gender-by-time interaction ≤ 0.0001. PD, pharmacodynamic; QTcF, corrected QT interval using Fridericia's formula.