TABLE 1.
Plasma pharmacokinetic parameters of delafloxacina
| Parameter | Mean (CV) or median (minimum, maximum) plasma PK values for delafloxacin (PK population) |
|
|---|---|---|
| 300 mg (therapeutic dose) (n = 52) | 900 mg (supratherapeutic dose) (n = 51) | |
| AUC0–24, μg · h/ml | 25.4 (28) | 98.7 (30) |
| Cmax, μg/ml | 9.82 (22) | 33.3 (23) |
| Tmax, hb | 1.00 (0.80, 1.10) | 1.00 (1.00, 1.12) |
a
AUC, area under the concentration-time curve; Cmax, maximum plasma concentration; CV, coefficient of variation; PK, pharmacokinetic; Tmax, time to achieve maximum observed plasma concentration.
b
For Tmax, the median (minimum, maximum) values are presented.