TABLE 2.
Ex vivo drug sensitivity data of isolated parasitesa
| Drug used | No. of samples | Geometric mean IC50 (nM) | 95% CI (nM)b | Range (nM) | Cutoff for resistance (nM) | No. (%) resistant |
|---|---|---|---|---|---|---|
| Chloroquine | 408 | 247.9 | 223.1–275.4 | 31.0–1,398 | 100 | 317 (77.7) |
| Quinine | 419 | 126.7 | 115.5–138.9 | 30.7–1,339 | 600 | 37 (8.8) |
| MDAQ | 421 | 76.9 | 70.2–84.1 | 12.5–564.6 | 100 | 157 (37.3) |
| DHA | 442 | 1.4 | 1.3–1.5 | 0.3–16.9 | 10 | 8 (1.8) |
| Lumefantrine | 378 | 3.0 | 2.6–3.3 | 0.4–24.4 | 50 | 0 (0) |
| Piperaquine | 381 | 19.1 | 17.1–21.4 | 3.1–188.9 | 100 | 35 (9.2) |
a
This table includes results for all samples studied. Results are stratified into different trials and study arms in Table S3 in the supplemental material.
b
95% CI, 95% confidence interval.