FIG 5.

In vivo efficacy of aglycosylated MAbs. Mice were passively immunized with a minimal protective dose (A) or an excessive dose (B) of three different O25b-specific MAbs and their aglycosylated variants. Survival curves following a subsequent lethal challenge by strain 81009 are shown. Graphs show combined results of 2 independent experiments with groups of 5 mice each. P values (log rank test) are shown where survival was significantly different relative to the control group (**, P < 0.01; ***, P < 0.001).