FIG 1.
Major structural features of plasmids pCA08 (ST131, blaCTX-M-14), pCA14 (ST131, blaCTX-M-15), and pCA28 (ST44, blaCTX-M-15) indicated with bold type compared with IncF plasmids pIP1206 (AM886293), pRSB225 (JX127248), and pKF3-140 (FJ876827), the IncF blaCTX-M-15-harboring plasmid pEC958 (HG941719), and the IncF blaCTX-M-14-harboring plasmid pETN48 (FQ482074). Light blue shades mainly indicate shared backbone regions and virulence factors with a high degree of similarity (>90% identity of nucleotide sequence). Open reading frames (ORFs) are portrayed by arrows and colored according to their putative functions. Dark-blue arrows indicate replication-associated genes. Genes associated with plasmid conjugal transfer are indicated by green arrows, and genes involved with plasmid stability are indicated by brown arrows. Red and yellow arrows indicate antimicrobial resistance genes and mobile element genes, respectively. Genes involved with virulence and biochemical pathways are indicated by dark-purple arrows. Gray arrows indicate genes for hypothetical proteins, as well as proteins of unknown function. UK, United Kingdom; DE, Germany; FR, France; CN, China.