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HO-1 up-regulation induced resistance to IM in K562 cells. A, as a result of silencing HO-1 expression in K562R cells, the apoptosis induced by IM was increased significantly. B, up-regulation of HO-1 in K562 cells mediated by lentivirus leaded to IM resistance. Con, control. ** indicates p < 0.01, and ## indicates p < 0.01.
