FIGURE 7.

Inhibition of HO-1 enhanced apoptosis induced by IM in CML. A, K562R cells were treated by IM (2 μm) plus ZnPP IX (1 μm) for 12 h. Then, whole cells lysates were prepared and subjected to Western blot analysis with antibodies against anti-cleaved caspase-3 (Cleaved-C3) and PARP-1 (Cleaved-P) in K562R cells. B, five IM-insensitive CML patients were randomly selected to measure cell viability after treatment with IM alone and with IM plus cariporide or ZnPP IX. Cell viability was detected by CCK-8 assay. ** indicates p < 0.01, and * indicates p < 0.05.