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Binding constants determined by surface plasmon resonance
| SIRPα allele | CD47 | kON | kOFF | KD | t½ |
|---|---|---|---|---|---|
| m−1 s−1 | s−1 | m | min | ||
| a1d1 | WT | 6.1 × 105 | 3.7 × 10−1 | 2.9 × 10−7 | 0.031 |
| N3612 | 1.5 × 105 | 5.7 × 10−4 | 3.7 × 10−10 | 20 | |
| a2d1 | WT | 3.0 × 105 | 4.8 × 10−1 | 4.8 × 10−7 | 0.024 |
| N3612 | 1.3 × 106 | 3.2 × 10−3 | 2.5 × 10−9 | 3.6 |
