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. 2015 Mar 30;290(20):12879–12898. doi: 10.1074/jbc.M114.634493

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 12. — Structure-activity relationship for UC-857993. UC-857993 and related structural analogs were assayed for their ability to dose-dependently inhibit 50 nm His₆-SOS1_cat-mediated BODIPY-TR-GTP loading on 2 μm His₆-H-Ras (residues 1–166) in the 96-well format. The structural relationships of UC-857993 and related analogs are displayed as a flow diagram based upon experimental activity and chemical structure. IC₅₀ values were calculated based upon nonlinear regression analysis (GraphPad Prism 6) at a single time point of 900 s and are displayed in the table. IC₅₀ values represent the mean ± S.E. of three independent experiments. NA, no activity.