Table 1.
Baseline characteristics of prospective study populations
| ACTIVE-A | CURE | epiDREAM/DREAM | ONTARGET | RE-LY | WGHS | |
|---|---|---|---|---|---|---|
| n | 1061 | 4662 | 14 104 | 3610 | 2501 | 23 294 |
| Mean age (SD) | 71.0 (9.9) | 63.6 (11) | 52.0 (11) | 67.0 (7.3) | 71.9 (7.4) | 54.2 (7.1) |
| Female (%) | 483 (45.5) | 1921 (41.2) | 8589 (60.9) | 998 (27.6) | 804 (32.1) | 23 294 (100) |
| BMI (kg/m2) (SD) | 29.1 (5.6) | 27.7 (4.2) | 30.0 (5.8) | 29.8 (5.2) | 29.2 (5.5) | 25.9 (5.0) |
| Previous CAD (%) | 314 (29.6) | 4662 (100) | 114 (0.81) | 2882 (79.8) | 799 (31.9) | 0 (0) |
| Diabetes (%) | 222 (20.9) | 994 (21.3) | 1842 (13.1) | 1909 (52.9) | 495 (19.8) | 586 (2.5) |
| High blood pressure (%) | 908 (85.6) | 2852 (61.2) | 5011 (35.5) | 529 (14.7) | 1884 (75.3) | 5730 (24.6) |
| Current smoking (%) | 81 (7.6) | 1048 (22.5) | 2049 (14.5) | 393 (10.9) | 226 (9.0) | 2710 (11.6) |
| Aspirin use (%) | 1061 (100) | 4662 (100) | 1535 (10.9) | 2843 (78.8) | 727 (29.1) | 11 617 (50) |
| rs20417 carrier status, n (%) | ||||||
| Carriers | 318 (30.0) | 1233 (26.4) | 4802 (34.0) | 857 (23.7) | 581 (23.2) | 6794 (29.2) |
| Non-carriers | 743 (70.0) | 3429 (73.6) | 9301 (66.0) | 2753 (76.3) | 1920 (76.8) | 16 490 (70.8) |
| Median follow-up (years) | 3.5 | 0.8 | 3.6 | 2.6 | 2.1 | 10.2 |
| Major cardiovascular events | ||||||
| n events | 247 | 456 | 131 | 565 | 87 | 518 |
| Events per 100 person-years (95% CI) | 7.3 (6.3–8.3) | 16.2 (14.7–17.7) | 0.3 (0.2–0.3) | 3.5 (3.2–3.8) | 1.7 (1.3–2.1) | 0.2 (0.2–0.2) |
| Vascular death | ||||||
| n events | 165 | 239 | 20 | 228 | 46 | 135 |
| Events per 1000 person-years (95% CI) | 4.8 (4.0–5.5) | 7.7 (6.7–8.8) | 0.05 (0.03–0.07) | 1.3 (1.2–1.5) | 0.8 (0.5–1.1) | 0.58 (0.48–0.68) |
| Myocardial infarction | ||||||
| n events | 43 | 255 | 86 | 269 | 43 | 217 |
| Events per 100 person-years (95% CI) | 1.2 (0.8–1.6) | 9.5 (8.3–10.7) | 0.2 (0.1–0.2) | 1.6 (1.4–1.9) | 0.8 (0.5–1.1) | 0.09 (0.08–0.11) |
| Stroke | ||||||
| n events | 105 | 55 | 48 | 157 | 46 | 270 |
| Events per 100 person-years (95% CI) | 3.1 (2.5–3.8) | 2.0 (1.4–2.5) | 0.1 (0.08–0.1) | 1.0 (0.8–1.1) | 0.8 (0.5–1.1) | 0.12 (0.10–0.13) |