FIG. 6.

Impact of sulforaphane on DNA methylation and histone-modifying enzymes on the regulation of genes commonly dysregulated during carcinogenesis. Inhibition/modulation of HDAC and DNMT activity by sulforaphane may lead to the reactivation of epigenetically silenced genes in order to enhance chemoprevention. Further studies are required in order to completely elucidate the significance of sulforaphane in the regulation of epigenetic changes, including its ability to modulate microRNA expression (not illustrated).