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. 2015 Apr 2;12:9. doi: 10.1186/s12987-015-0004-z

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© Ivkovic et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Observed changes in T1-hypointensities and mean diffusivity after treatment. Left: Decrease in volume of T1-hypointensities (y axis) was higher among patients that experienced clinical improvement (red bar, ELD-improvement (N = 7) vs. ELD-no-improvement (purple bar set to zero N = 5): p = 0.008, and between ACZ-improvement (pink bar, N = 7) relative to no-intervention (blue bar, N = 5): p = 0.002). Patients that were not subject to intervention showed an increase in T1-hypointensities (blue bar). Right: Percentage decrease in DW-MRI mean diffusivity (MD) within remaining T1-hypointensites was higher in patients that experienced clinical improvement (ELD-improvement vs. ELD-No-Improvement: p = 0.007, ACZ vs. No-Intervention: p = 0.0002). Data are means +/− SEM.