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. 2015 Apr 2;12:9. doi: 10.1186/s12987-015-0004-z

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© Ivkovic et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A subject with remarkable long-term correlation between cognitive scores and T1-hypointensities volume. Left: Correlation between Alzheimer’s Disease Assessment Scale (ADAS) cognitive scores and the volume of the white matter T1-hypointensities, over a 5 year period, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) subject 0644 (an MCI case). All the data points were independently calculated and available at the ADNI portal [39]. Right: Hallmarks of CSF dysfunction on the same subject: ventriculomegaly and DESH pattern. Note lacunae in the deep gray matter, consistent with the radiologic presentation of dilated veins observed in untreated NPH patients [40].