Table 5.
Down-regulated genes in the residual cervical cancer after 50 Gy dose of radiation at least fourfold higher.
| Gene_symbol | GenBank accession | Description | Foldchange | P values |
|---|---|---|---|---|
| MEST | NM_177525 | Mesoderm specific transcript homolog (mouse) | 19.03931 | 0.0008 |
| CDKN3 | NM_001130851 | Cyclin-dependent kinase inhibitor 3 | 15.72590 | 0.0079 |
| HES6 | NM_001142853 | Hairy and enhancer of split 6 (Drosophila) | 13.30584 | 0.0035 |
| CENPN | NM_001100624 | Centromere protein N | 13.19284 | 0.0010 |
| CDC6 | NM_001254 | Cell division cycle 6 homolog (S. cerevisiae) | 12.67188 | 0.0002 |
| MCM10 | NM_018518 | Minichromosome maintenance complex component 10 | 12.42256 | 0.0043 |
| MND1 | NM_001253861 | Meiotic nuclear divisions 1 homolog (S. cerevisiae) | 12.38095 | 0.0067 |
| ZNF367 | NM_153695 | Zinc finger protein 367 | 12.13090 | 0.0004 |
| GINS1 | NM_021067 | GINS complex subunit 1 (Psf1 homolog) | 11.95449 | 0.0011 |
| PRC1 | NM_003981 | Protein regulator of cytokinesis 1 | 11.78833 | 0.0099 |
| KIAA0101 | NM_014736 | KIAA0101 | 11.48251 | 0.0079 |
| ESCO2 | NM_001017420 | Establishment of cohesion 1 homolog 2 (S. cerevisiae) | 11.18837 | 0.0085 |
| FAM64A | NM_019013 | Family with sequence similarity 64, member A | 10.46812 | 0.0044 |
| TMEM97 | NM_014573 | Transmembrane protein 97 | 10.36410 | 0.0046 |
| STMN1 | NM_203401 | Stathmin 1 | 9.814851 | 0.0012 |
| MLF1IP | NM_024629 | MLF1 interacting protein | 9.786415 | 0.0005 |
| TK1 | NM_003258 | Thymidine kinase 1, soluble | 9.528579 | 0.0014 |
| E2F7 | NM_203394 | E2F transcription factor 7 | 9.295376 | 0.0050 |
| BIRC5 | NM_001012270 | Baculoviral IAP repeat containing 5 | 9.246912 | 0.0082 |
| GINS2 | NM_016095 | GINS complex subunit 2 (Psf2 homolog) | 9.024759 | 0.0030 |
| FAM111B | NM_001142703 | Family with sequence similarity 111, member B | 8.962451 | 0.0034 |
| ORC6 | NM_014321 | Origin recognition complex, subunit 6 | 8.926719 | 0.0050 |
| GGH | NM_003878 | Gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 8.558582 | 0.0071 |
| CDC45 | NM_001178010 | Cell division cycle 45 homolog (S. cerevisiae) | 8.505507 | 0.0098 |
| PXMP2 | NM_018663 | Peroxisomal membrane protein 2, 22kDa | 8.168918 | 0.0096 |
| CDT1 | NM_030928 | Chromatin licensing and DNA replication factor 1 | 7.987140 | 0.0047 |
| RNASEH2A | NM_006397 | Ribonuclease H2, subunit A | 7.735180 | 0.0001 |
| CHML | NM_001821 | Choroideremia-like (Rab escort protein 2) | 7.648427 | 0.0001 |
| FANCI | NM_001113378 | Fanconi anemia, complementation group I | 7.272155 | 0.0044 |
| EXO1 | NM_003686 | Exonuclease 1 | 6.787611 | 0.0037 |
| RFC4 | NM_002916 | Replication factor C (activator 1) 4 | 6.678417 | 0.0062 |
| C1orf112 | NM_018186 | Chromosome 1 open reading frame 112 | 6.629925 | 0.0022 |
| KLHL23 | NM_001199290 | Kelch-like 23 (Drosophila) | 6.565550 | 0.0088 |
| ATAD2 | NM_014109 | ATPase family, AAA domain containing 2 | 6.412012 | 0.0074 |
| CCNE1 | NM_001238 | Cyclin E1 | 6.285823 | 0.0003 |
| KIF15 | NM_020242 | Kinesin family member 15 | 6.28417 | 0.0096 |
| MCM4 | NM_005914 | Minichromosome maintenance complex component 4 | 6.21293 | 0.0065 |
| DSCC1 | NM_024094 | Defective in sister chromatid cohesion 1 homolog (S. cerevisiae) | 6.19047 | 0.0099 |
| TMEM106C | NM_001143841 | Transmembrane protein 106C | 6.01842 | 0.0073 |
| HOMER1 | NM_004272 | Homer homolog 1 (Drosophila) | 5.89936 | 0.0095 |
| CHEK1 | NM_001114121 | Checkpoint kinase 1 | 5.67529 | 0.0003 |
| RAD51C | NM_002876 | RAD51 homolog C (S. cerevisiae) | 5.62493 | 0.0020 |
| MIS18A | NM_018944 | MIS18 kinetochore protein homolog A (S. pombe) | 5.61498 | 0.0074 |
| BRCA1 | NM_007294 | Breast cancer 1, early onset | 5.51289 | 0.0061 |
| MSH2 | NM_000251 | MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 5.40957 | 0.0082 |
| RFC5 | NM_001130112 | Replication factor C (activator 1) 5, 36.5kDa | 5.40903 | 0.0081 |
| VRK1 | NM_003384 | Vaccinia related kinase 1 | 5.38942 | 0.0011 |
| CCDC58 | NM_001017928 | Coiled-coil domain containing 58 | 5.38923 | 0.0072 |