Table 5.

Mean and standard deviation of tract mean FA in the 19 extracted fiber connections (A)–(S) (column 1) that were detected in the subsample of 24 participants having three MRI examinations: at baseline (column 2), at first follow-up (column 3) and at second follow-up (column 4).

Connection	Wave-1	Wave-2	Wave-3	P-value	N	% ΔFA/year
(A) LH Thal ↔ SF	0.386 ± 0.033	0.376 ± 0.022	0.384 ± 0.032	0.922	21	−0.19
(B) LH Ca ↔ SF	0.350 ± 0.042	0.325 ± 0.036	0.331 ± 0.029	0.150	19	−0.43
(C) LH Pu ↔ SF	0.384 ± 0.031	0.368 ± 0.032	0.365 ± 0.024	0.229	20	−0.25
(D) LH Ca ↔ MOF	0.320 ± 0.021	0.309 ± 0.023	0.308 ± 0.029	<0.001	24	−1.45
(E) RH Ca ↔ MOF	0.326 ± 0.030	0.323 ± 0.026	0.315 ± 0.029	<0.001	23	−1.48
(F) LH Pu ↔ MOF	0.334 ± 0.022	0.323 ± 0.029	0.322 ± 0.036	0.006	20	−1.11
(G) LH Ac ↔ MOF	0.262 ± 0.041	0.261 ± 0.032	0.244 ± 0.035	0.214	19	−0.28
(H) LH Ca ↔ LOF	0.343 ± 0.023	0.324 ± 0.026	0.325 ± 0.027	<0.001	24	−1.71
(I) RH Ca ↔ LOF	0.339 ± 0.021	0.332 ± 0.025	0.331 ± 0.024	<0.001	24	−1.71
(J) LH Pu ↔ LOF	0.360 ± 0.022	0.361 ± 0.225	0.363 ± 0.023	0.098	24	−0.46
(K) RH Pu ↔ LOF	0.366 ± 0.024	0.364 ± 0.020	0.362 ± 0.018	0.019	24	−0.50
(L) LH Pu ↔ PT	0.371 ± 0.023	0.378 ± 0.030	0.380 ± 0.025	0.793	24	−0.07
(M) RH Pu ↔ PT	0.369 ± 0.021	0.363 ± 0.021	0.366 ± 0.021	<0.005	24	−0.52
(N) LH Thal ↔ RMF	0.359 ± 0.025	0.348 ± 0.025	0.349 ± 0.026	0.052	19	−0.45
(O) RH Thal ↔ RMF	0.375 ± 0.019	0.367 ± 0.029	0.369 ± 0.027	<0.001	22	−1.02
(P) LH Ca ↔ RMF	0.334 ± 0.020	0.321 ± 0.019	0.324 ± 0.018	<0.001	24	−1.29
(Q) RH Ca ↔ RMF	0.338 ± 0.024	0.333 ± 0.030	0.335 ± 0.022	<0.001	24	−1.42
(R) LH Pu ↔ RMF	0.355 ± 0.019	0.356 ± 0.023	0.355 ± 0.024	0.077	24	−0.45
(S) RH Pu ↔ RMF	0.363 ± 0.023	0.358 ± 0.020	0.356 ± 0.019	<0.001	24	−0.75

N (≤ 24; column 6) denotes the total number of subjects for which the specific fiber bundle could be identified according to the given criteria. See Table 4 for further descriptions.