Table 7.

Mean and standard deviation of tract mean FA in the in the anterior callosal fiber (ACF) bundle, and in left and right hemispheres (LH, RH) of the corticospinal tract (CST) that were detected in the subsample of 24 participants having three MRI examinations: at baseline (column 2), at first follow-up (column 3), and at second follow-up (column 4).

Tract	Wave-1	Wave-2	Wave-3	P-value	N	% ΔFA/year
ACF	0.446 ± 0.027	0.423 ± 0.024	0.419 ± 0.029	<0.001	24	−1.34
LH CST	0.434 ± 0.022	0.439 ± 0.018	0.432 ± 0.017	<0.001	24	−0.23
RH CST	0.421 ± 0.031	0.430 ± 0.030	0.427 ± 0.028	0.016	24	0.10

N (≤ 24; column 6) denotes the total number of subjects for which the specific fiber bundle could be identified according to the given criteria. P-value (column 5) is calculated from repeated measures ANOVA across Wave-1, Wave-2, and Wave-3. Significant change is marked by bold values. Column 7 provide percentage annual change of tract mean FA (calculated first for each subject and than averaged across the total sample).