Fig. 1.
Human Nav1.8 channels produce a larger persistent current than rat Nav1.8 channels in transfected Nav1.8-knockout dorsal root ganglion (DRG) neurons. A and B: representative Nav1.8 current family traces recorded from mouse Nav1.8-knockout DRG neurons transfected with rat (A) or human (B) Nav1.8 channels. Cells were held at −70 mV and stepped to a range of potentials (−70 to +40 mV in 5-mV increments) for 100 ms. C and D: comparison of the absolute value (C) and normalized value (D) of persistent currents between rat and human Nav1.8 channels.