Fig. 3.
DRG neurons transfected with human Nav1.8 channels generate different firing patterns. A: representative type I response: the response to a 200-ms depolarizing stimulus has only 1 single spike, and the action potential half-width is smaller than 10 ms. Vm, membrane voltage. B and C: representative type II response: half-width of the first action potential larger than 10 ms (B) and extremely long action potential (C). Inset in C shows the full length of this extremely broad action potential. D: representative bursting firing response: the first all-or-none response has a burst of multiple spikes.