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. 2015 Mar 18;113(9):3172–3185. doi: 10.1152/jn.00113.2015

Fig. 5.

Fig. 5.

For DRG neurons displaying type I evoked firing, neurons expressing human Nav1.8 channels are more excitable than neurons expressing rat Nav1.8 channels. A: responses of representative DRG neurons expressing rat (top) and human (bottom) Nav1.8 channels to 50-pA, 100-pA, 200-pA, and 400-pA (from left to right), 500-ms depolarization current injections. B: comparison of responses (number of impulses evoked by a 500-ms stimulus) in DRG neurons expressing human (n = 26) or rat (n = 36) Nav1.8 channels across a range of step current injections from 50 to 500 pA. *P < 0.05.