Table 1.
Comparison of biophysical properties between human Nav1.8 and rat Nav1.8
Activation |
Fast Inactivation |
||||||||
---|---|---|---|---|---|---|---|---|---|
V1/2,act, mV | n | V1/2,fast, mV | Offset | n | Ramp Current | n | Persistent Current | n | |
Rat Nav1.8 | −6.21 ± 1.62 | 17 | −35.53 ± 1.6 | 2.25 ± 0.42% | 16 | 12.1 ± 2.1% | 9 | 4.2 ± 0.4% | 17 |
Human Nav1.8 | −11.12 ± 1.76* | 17 | −31.86 ± 0.58* | 9.2 ± 1.61%*** | 15 | 21.9 ± 1.1%** | 12 | 12.3 ± 1.3%*** | 17 |
Values are means ± SE. V1/2,act, V1/2,fast, potential at which activation or fast inactivation is half-maximal.
P < 0.05,
P < 0.01,
P < 0.001.