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Binding properties of hIgG1 Fc-engineered variants toward C1q and complement factors. ELISA results showing binding of WT hIgG1 and Fc-engineered variants to (A) pure hC1q, (B) C1q present in human serum, and (C) pure C1q present in C1q-depleted human serum and activation of complement factors (D) C3 and (E) C5. Experiments were performed at pH 7.4 and results are shown as mean ± SEM of one representative experiment out of three.
