FIG 2.

Genome-wide transcript analysis of the Δmga strain compared to the wild type. (A) Gene expression in the MGAS15249 Δmga strain. The relative gene expression level in the Δmga:pDC strain compared to the Δmga:pDC-mga strain is shown. Mean fold changes in transcript levels of differentially regulated genes and their respective genomic coordinates are shown (P < 0.05 compared to the wild type, determined by Baggerly's test after applying Bonferroni's correction for multiple comparisons). (B to D) Genetic arrangement of significantly regulated genes in the Δmga:pDC strain (genes with a >10-fold change in transcript levels).