FIG 4.

Histopathological changes in 4-day S. aureus-infected dermal explants. (a) Uninfected explant; (b) S. aureus-infected explant. The arrow in panel a points to a fibroblast nucleus; no equivalent nucleus was present with infected dermal explant. An arrowhead highlights cellular detail in blood vessels in panel a, whereas the basophilic stippling associated with the vascular bundles in panel b appears to be nuclear debris. The double arrowheads in panel b point to biofilm on the explant surface.