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. 2015 Mar 14;6(1):31. doi: 10.1186/s13287-015-0017-1

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© Yaochite et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Intrapancreatic adipose tissue-derived mesenchymal stem cell transplantation does not increase serum insulin levels in diabetic treated mice. Pancreata from Control-PBS and adipose tissue-derived mesenchymal stem cell (ADMSC)-treated mice were collected 70 days after the treatment. Islet morphology was evaluated by hematoxylin and eosin (H&E) staining and the in situ insulin content was detected by immunohistochemistry assay. (A) Representative H&E and insulin-stained islets from the Control-PBS group (left panel) and the responder ADMSC-treated group (R-ADMSCs; right panel) are shown. Original magnification 100×. (B) The number of islets per section (left y axis) was counted and the islet area (right y axis) was determined. (C) Blood samples of nonfasting mice were collected at day 70 post transplantation and circulating-insulin levels were determined by enzyme-linked immunosorbent assay. Bars represent average ± standard deviation. *P <0.05 (Control-PBS vs. R-ADMSCs). NR-ADMSCs, nonresponder ADMSC-treated mice; PBS, phosphate-buffered saline.