Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 14;6(1):31. doi: 10.1186/s13287-015-0017-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Yaochite et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Intrasplenic and intrapancreatic adipose tissue-derived mesenchymal stem cell administrations do not change the frequency of regulatory T cells in the spleen and pancreatic lymph nodes of diabetic mice 70 days after cell transplantation. Frequency of regulatory CD4⁺CD25⁺Foxp3⁺ T (Treg) cells was analyzed by flow cytometry in cell suspensions obtained from the (A, C) spleen and (B, D) pancreatic lymph nodes (PLN) from adipose tissue-derived mesenchymal stem cell (ADMSC)-treated and phosphate-buffered saline (PBS)-treated mice. Cells were stained for surface markers CD4 and CD25 and subsequently for the transcription factor Foxp3. Bars represent average ± standard error of the mean. Intrasplenic route: Control-PBS, n = 5; R-ADMSCs, n = 7; NR-ADMSCs, n = 3. Intrapancreatic route: Control-PBS, n = 5; R-ADMSCs, n = 5; NR-ADMSCs, n = 7. NR-ADMSCs, nonresponder ADMSC-treated mice; R-ADMSCs, responder ADMSC-treated mice.